Fig. 1
Cutaneous melanoma polygenic risk score model performance in the validation cohort (QSkin). The x-axis represents the different melanoma polygenic risk score (PRS) modelling varying fractions of causal SNPs, 1 (F0), 0.1 (F1), 0.01 (F2), 0.001 (F3), 0.0001 (F4) and 0.00002 (F5), and differing linkage disequilibrium (LD) radii, 1 megabase (Mb), 2 Mb, 3 Mb, 4 Mb and 5 Mb. The y-axis represents Nagelkerke's R2 (%) for each of the 30 PRS models. The horizontal dashed black line highlights the optimal model (F3 and 5 Mb) with the highest Nagelkerke’s R2 of 7.03%