Fig. 1

MARCH8 inhibits colorectal cancer (CRC) in vitro and in vivo. A MARCH8 expression in colorectal cells was examined. B Expression of MARCH8 in MARCH8-manipulated cells. C Proliferation curves and (D) apoptosis rates of MARCH8-manipulated CRC cells. E Tumour size in tumour tissues from the oeMAR mice and the vector mice. F Tumour growth curves of the oeMAR mice and the vector mice. G Quantification of apoptosis cell rates, as revealed by TUNEL assays, scale bar 50 μm. H Percentages of apoptotic cells in tumour tissues revealed by TUNEL assays. *P < 0.05, **P < 0.01, ***P < 0.001 vs. vector