Fig. 2

M2-polarized microglia promoted the proliferation of irradiated GBM cells by CCL2/CCR2. A M2-polarized HMC3 cells obviously promoted the proliferation of irradiated GBM cells. B GW4869 suppressed the growth of irradiated U251 cells and increased the efficacy of radiotherapy in the co-culture system of U251 and HMC3 cells in a zebrafish model. C GW4869 suppressed the growth of irradiated U87 cells and increased the efficacy of radiotherapy in a co-culture system of U87 and HMC3 cells in a zebrafish model. D The expression of CCR2 increased in U251 cells after radiation. E Knocked down CCR2 significantly relieved the proliferation of the radiated U251 cells by M2 HMC3 cells inducing