Table 3 The NICS performance of IVF versus ICSI in detecting chromosomal abnormalities
From: Non-invasive preimplantation genetic testing for conventional IVF blastocysts
Assay (n) | NICS amplification success rate, % (95% CI) | TE amplification success rate, % (95% CI) | Embryo | Assay (n) | Concordance, % (95% CI) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
IVF (161) | 91.3 (85.9–94.7) | 98.1 (94.7–99.5) | Original | IVF (144) | 62.5 (54.4–70.0) | 93.0 (84.6–97.0) | 32.9 (23.2–44.3) | 57.4 (48.3–66.1) | 82.8 (65.5–92.4) |
ICSI (122) | 96.7 (91.9–98.7) | 100 (96.9–100) | ICSI (118) | 67.0 (58.0–74.8) | 86.2 (75.7–92.5) | 43.4 (31.0–56.7) | 65.1 (54.6–74.4) | 71.9 (54.6–84.4) | |
p value | 0.064 | 0.352 | p value | 0.45 | 0.19 | 0.23 | 0.27 | 0.31 | |
|  |  |  | Adjusted | IVF-Adjusted (144) | 75.0 (67.3–81.4) | 91.4 (81.4–96.3) | 64.0 (53.4–73.3) | 63.1 (52.4–72.6) | 91.7 (81.9–96.4) |
|  |  |  | ICSI-Adjusted (118) | 74.6 (66.0–81.6) | 84.2 (72.6–91.5) | 65.6 (53.1–76.3) | 69.6 (57.9–79.2) | 81.6 (68.6–90.0) | |
| Â | Â | Â | p value | 0.94 | 0.24 | 0.84 | 0.40 | 0.12 |