Journal of Translational Medicine

Table 1 Interactions of the N-PepO with TLR2 and TLR4. Investigation of interactions was performed through DIMPLOT program from LigPlot⁺v2.2.4

From: In silico designing of a novel epitope-based candidate vaccine against Streptococcus pneumoniae with introduction of a new domain of PepO as adjuvant

N-PepO-TLR2						N-PepO-TLR4
N-PepO residues		TLR2 residues			H-bond distance	N-PepO residues		TLR4 residues		H-bond distance
Name	No	Name		No	H-bond distance	Name	No	Name	No	H-bond distance
Arg	354	Glu	264		2.74	Thr	19	Arg	67	2.79
Arg	354	Glu	264		2.71	Glu	21	Arg	67	2.84
Lys	357	Glu	264		2.75	Ala	11	Arg	87	2.77
Asp	34	Arg	321		2.73	Ile	12	Arg	87	3.06
Asp	34	Arg	321		2.69	Glu	15	Arg	87	2.78
Phe	8	Tyr	323		2.79	Asn	13	Gln	91	2.93
Tyr	9	Tyr	323		2.68	Tyr	4	Ser	184	2.97
Asn	13	Tyr	323		3.09	Tyr	4	Lys	186	2.59
Gln	5	Leu	328		2.95	Gln	5	Lys	186	2.59
Arg	3	Tyr	332		2.63	Gln	5	Glu	266	2.84
Gln	5	Tyr	332		2.75
Asp	6	Tyr	332		2.60
Glu	15	Lys	347		2.51
Arg	3	Leu	350		2.66

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ISSN: 1479-5876

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