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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Heme oxygenase 1 overexpression induces immune evasion of acute myeloid leukemia against natural killer cells by inhibiting CD48

Fig. 5

AML cell-derived xenograft (CDX) mice overexpressing HO1 were resistant to the killing effect of NK cells. A Schematic illustration showing the experimental design of THP-1luc mice experiments. B Representative tumor-bearing mice images in indicated cells. C Subcutaneous xenograft images from mice in EV1, LV-HO1, EV1 + NK cells, and LV-HO1 + NK cells groups. D Tumor volume growth curves for subcutaneous xenografts. E Tumor weight change curves for subcutaneous xenografts. F Survival curves for the subcutaneous xenografts. G HE and Ki67 staining in xenograft tumors mentioned above (HE, ×20 magnification; Ki67, ×20, ×40 magnification). The Ki67 immunohistochemistry scores were shown in histogram. *p < 0.05, **p < 0.01, ***p < 0.001, #p < 0.05 and ##p < 0.01 were calculated using the Student’s t-test

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