Fig. 2

Overexpression of HO1 inhibited CD48 in AML patients. A Heatmaps showing the relationship between HO1 expression and 47 immune checkpoint/ligand genes in 33 tumors. B CD48 and 2B4 expression as determined in HO1 high/low AML specimens by flow cytometry. C Correlation between HO1 and 10 immune checkpoint/ligand molecules. Statistical differences were determined using the Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001. ns no significance