Table 3 GCX-and endothelial-related proteins in ISCLS plasma
From: Markers of endothelial glycocalyx dysfunction in Clarkson disease
Protein | Fold increase (acute vs. remission) | p value | Category |
|---|---|---|---|
GPC2 | 3.06 | 0.0017 | GCX proteoglycan |
GPC6 | 2.57 | 0.009 | GCX proteoglycan |
TSP-1 | 3 | 0.0002 | GCX proteoglycan |
MMP1 | 2.61 | 0.002 | Protease |
MMP8 | 7.92 | 0.02 | Protease |
MMP9 | 4.54 | 0.0004 | Protease |
MMP13 | 1.66 | 0.006 | Protease |
MMP14 | 1.8 | 0.03 | Protease |
MMP17 | 2.45 | 0.001 | Protease |
ADAM12 | 2.64 | 0.003 | Protease |
ADAMTS1 | 3.13 | 0.002 | Protease |
ADAMTS4 | 2.28 | 0.009 | Protease |
ADAMTS15 | 2.44 | 0.0013 | Protease |
ADAMTS13 | −1.06 | 0.69 | EC-derived protease [27] |
Coagulation factor III (tissue factor) | 1.39 | 0.08 | Endothelial damage |
vWF | 1.29 | 0.37 | Endothelial damage [21] |
sICAM1 | 1.18 | 0.15 | Endothelial activation/damage [27] |
VCAM1 | 1.13 | 0.24 | Endothelial activation |
sE-selectin | −1.04 | 0.63 | Endothelial activation |