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Table 1 Comparison of clinical data for NSCLC patients in non-DDR, DDR-somatic, and DDR-germline groups

From: Pathogenic somatic alterations of DDR genes in lung cancer are significantly different from germline mutations and are associated with more unstable genomes

Characteristics

N

Level

non_DDR N (%)

DDR_somatic N (%)

DDR_germline N (%)

P value

Total

5235

 

3096

1489

650

 

Age

5232

 

62 (16–94)

64 (23–107)

62 (27–92)

1.43E−07

Gender

5235

Female

1590 (51.36%)

554 (37.21%)

293 (45.08%)

1.9443E−18

Male

1506 (48.64%)

935 (62.79%)

357 (54.92%)

 

Stage

2380

I

255 (19.26%)

48 (6.43%)

48 (15.48%)

5.2446E−13

II

129 (9.74%)

59 (7.91%)

29 (9.35%)

III

242 (18.28%)

157 (21.05%)

64 (20.65%)

IV

698 (52.72%)

482 (64.61%)

169 (54.52%)

Dignosis

3888

NSCLC

2266 (98.65%)

1075 (96.85%)

475 (98.75%)

0.00071134

SCLC

31 (1.35%)

35 (3.15%)

6 (1.25%)

Subtype

3544

LUAD

1923 (91.22%)

827 (82.95%)

382 (87.02%)

1.0291E−09

LUSC

148 (7.02%)

140 (14.04%)

50 (11.39%)

Others

37 (1.76%)

30 (3.01%)

7 (1.59%)