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Table 2 Performance of cfDNA testing with or without enrichment for detecting fetal chromosomal aneuploidy in early pregnancy loss

From: A fetal fraction enrichment method reduces false negatives and increases test success rate of fetal chromosome aneuploidy detection in early pregnancy loss

  SNP array result cfDNA testing without enrichment cfDNA testing with enrichment
FF (%) Z-score FF (%) Z-score
Case1 47, XY, + 21 23.6 19.0 59.0 28.5
Case2 47, XY, + 21 19.4 12.9 56.3 25.7
Case3 47, XY, + 22 9.7 6.2 34 15.8
Case4 47, XY, + 18 4.2 5 18.6 9.1
Case5 47, XX, + 8 11.3 2.7 28.3 8.2
Case6 47, XY, + 22 2.8 2.3 17.5 7.5
Case7 45, XO 5.1 − 2.9 21 − 7.5
Case8 47, XY, + 13 10 8.4 30.1 15.3