Table 2 Performance of cfDNA testing with or without enrichment for detecting fetal chromosomal aneuploidy in early pregnancy loss
SNP array result | cfDNA testing without enrichment | cfDNA testing with enrichment | |||
|---|---|---|---|---|---|
FF (%) | Z-score | FF (%) | Z-score | ||
Case1 | 47, XY, + 21 | 23.6 | 19.0 | 59.0 | 28.5 |
Case2 | 47, XY, + 21 | 19.4 | 12.9 | 56.3 | 25.7 |
Case3 | 47, XY, + 22 | 9.7 | 6.2 | 34 | 15.8 |
Case4 | 47, XY, + 18 | 4.2 | 5 | 18.6 | 9.1 |
Case5 | 47, XX, + 8 | 11.3 | 2.7 | 28.3 | 8.2 |
Case6 | 47, XY, + 22 | 2.8 | 2.3 | 17.5 | 7.5 |
Case7 | 45, XO | 5.1 | − 2.9 | 21 | − 7.5 |
Case8 | 47, XY, + 13 | 10 | 8.4 | 30.1 | 15.3 |