From: Non-coding RNAs in lung cancer: emerging regulators of angiogenesis
NcRNAs | Expression | Target gene and pathway | Angiogenic Effect | Type of lung cancer | References |
---|---|---|---|---|---|
miR-29c | Down-regulation | VEGFA | Inhibits | LUAD | [39] |
miR-519c | Down-regulation | HIF-1α/VEGFA axis | Inhibits | NSCLC | [40] |
let-7b/miR-126 | Down-regulation | VEGFA | Inhibits | NSCLC | [41] |
miR-145-5p | Down-regulation | CP | Inhibits | LUAD | [42] |
miR-320b | Down-regulation | HNF4G | Inhibits | NSCLC | [43] |
miR-497 | Down-regulation | HDGF and VEGFA | Inhibits | NSCLC | [51] |
miR-141 | Up-regulation | KLF12 and GAX | Activates | SCLC, NSCLC | |
miR-619-5p | Up-regulation | RCAN1.4 | Activates | NSCLC | [56] |
LINC00173 V1 | Up-regulation | miR-511-5p/VEGFR axis | Activates | LUSC | [60] |
lncRNA MCM3AP-AS1 | Up-regulation | miR-340-5p/KPNA4 axis | Activates | NSCLC | [61] |
linc00665 | Up-regulation | YB1/VEGFA axis | Activates | LUAD | [62] |
lncRNA TNK2-AS1 | Up-regulation | STAT3/VEGFA axis | Activates | NSCLC | [63] |
linc00941 | Up-regulation | miR-877-3p/VEGFA axis | Activates | NSCLC | [67] |
lncRNA F630028O10Rik | Up-regulation | miR-223-3p/VEGFA axis and VEGFR2 | Activates | NSCLC | [68] |
lncRNA FBXL19-AS1 | Up-regulation | miR-431-5p/RAF1 axis | Activates | NSCLC | [69] |
lncRNA CCAT1 | Up-regulation | N/A | Activates | LUAD | [70] |
lincRNA-p21 | Up-regulation | N/A | Activates | NSCLC | [72] |
circ_0006988 | Up-regulation | miR-491-5p/MAP3K3 axis | Activates | NSCLC | [73] |
circ_0016760 | Up-regulation | miR-29b/HIF1α axis | Activates | NSCLC | [74] |
miR-942 | Up-regulation | FOXO1 | Activates | LUAD | [75] |
miR-31 | Up-regulation | FOXO3a | Activates | NSCLC | [79] |
miR-206 | Down-regulation | VEGFA/CCL2 | Inhibits | NSCLC | [79] |
miR-1 | Down-regulation | VEGFA/CCL2 and MPL | Inhibits | NSCLC | |
miR-210 | Up-regulation | JAK2/STAT3 signaling and TET2 | Activates | NSCLC | [79] |
miR-224 | Up-regulation | SIRT3/AMPK axis | Activates | NSCLC | [80] |
miR-103a | Up-regulation | PTEN | Activates | NSCLC | [81] |
miR-128 | Down-regulation | VEGFC | Inhibits | NSCLC | [82] |
miR-200b | Down-regulation | QKI/CCND1 axis | Inhibits | NSCLC | [85] |
miR-192 | Down-regulation | IL-8, ICAM and CXCL1 | Inhibits | LUAD | [86] |
miR-494 | Up-regulation | PTEN | Activates | NSCLC | [87] |
miR-21 | Up-regulation | STAT3/VEGF axis | Activates | N/A | [88] |
miR-23a | Up-regulation | PHD1 and PHD2 | Activates | NSCLC | [89] |
lncRNA EPIC1 | Up-regulation | Ang2/Tie2 axis | Activates | NSCLC | [91] |
lncRNA GAS5 | Down-regulation | miRNA-29-3p/PTEN axis | Inhibits | NSCLC | [92] |