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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis

Fig. 7

High Serpin E1 expression in gastric cancer tissues from the TCGA-STAD database and patients with gastric cancer. A Analysis of the TCGA-STAD dataset, including 408 tumors and 211 normal tissues, shows the upregulation of Serpin E1 mRNA expression in gastric cancer tissues. *P < 0.05. B Kaplan–Meier survival curve shows an inverse correlation of Serpin E1 mRNA level with the ten-year overall survival of patients with gastric cancer based on the TCGA-STAD dataset. C IHC staining for Serpin E1 and FAP in clinical gastric cancer samples (n = 12). Scale bar: 100 μm for the upper left images and 50 μm for the remaining images. D Quantification of IHC staining for Serpin E1 and FAP. IHC scores = intensity score × percentage score. Data are presented as means ± SD from 12 independent samples. *P < 0.05 and *** P < 0.001. E Spearman correlation analysis between Serpin E1 and FAP expression in 24 clinical gastric tissue samples. F A possible mechanism of H. pylori-NFs/CAFs-cancer cells crosstalk in gastric tumorigenesis

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Journal of Translational Medicine

ISSN: 1479-5876

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