Fig. 3

Correlation analysis between the expression of PROS1 and the expression levels of methyltransferases, RNA Modifications Genes, DNA Mismatch Repair System (MMRs) Genes, Copy Number Variation (CNV), and Single nucleotide variation (SNV) frequency. A Correlation analysis of PROS1 expression with that of 4 DNA methyltransferases (DNMT1 was colored red, DNMT2 was colored blue, DNMT3a was colored green, and DNMT3b is colored purple) in pan-cancer. B Correlation analysis of PROS1 expression with 44 RNA modifications genes (m1A(10)、m5C(13)、m6A(21)) in pan-cancer. C Correlation analysis of PROS1 expression with with the mutation levels of 5 MMR genes (MLH1, MSH2, MSH6, PMS2, and EPCAM) in pan-cancer. D Lollipop plot displaying mutation distribution and protein domains for PROS1 in cancer with the labeled recurrent hotspots. E Correlation analysis of PROS1 expression with CNV alternation in three groups (Neutral = 491, Loss = 14, Gain = 3) tested by by kruskal method. F Oncoplot displaying the somatic landscape of low grade gliomas cohort