Fig. 8

The NRG signature predicted the responses to ICIs. A Heat map for scores of seven tumor-immune cycle steps in high- and low-risk groups. B Correlations between the risk scores, CAF, TAM, MDSC, TIDE scores, dysfunction, and exclusion. C Correlations between the risk scores and the expression levels of PD-1 and the KM survival curve in groups divided by PD-1 expression and risk scores. D Correlations between the risk scores and the expression levels of PD-L1 and the KM survival curve in groups divided by PD-L1 expression and risk scores. E Correlations between the risk scores and the expression levels of CTLA-4 and the KM survival curve in groups divided by CTLA-4 expression and risk scores. F Violin plots for ips of 4 subtypes divided by the response to anti-PD-1 and anti-CTLA4 immunotherapy in the two risk groups. G Heat map for the response possibility of anti-PD-1 and anti-CTLA-4 treatment in the two risk groups. ***P < 0.001