Fig. 3
From: TA-MSCs, TA-MSCs-EVs, MIF: their crosstalk in immunosuppressive tumor microenvironment
A Highly expressed MIF in tumors and stroma induce MSCs homing to TME. B After homing to tumor, MSCs are subsequently educated by tumor cells and TME to transform into TA-MSCs. C TA-MSCs-EVs promote the proliferation, migration and invasion of tumor cells through MIF transport, thus promoting tumor progression. D High levels of MIF in TME protect TA-MSCs from senescence and apoptosis