Bladder cancer-derived exosomal KRT6B promotes invasion and metastasis by inducing EMT and regulating the immune microenvironment

Table 1 The top 20 differently expressed exosomal genes in TCGA

Gene symbol	Description	Normal	Tumor	logFC	P-value	FDR
UP
ALPP	Alkaline phosphatase, placental	10.634	690.697	6.021	< 0.001	< 0.001
KRT14	Keratin 14	1487.308	31,827.192	4.419	< 0.001	< 0.001
RNASE7	Ribonuclease A family member 7	35.990	218.149	2.600	0.003	0.007
LAMC2	Laminin subunit gamma 2	2561.991	13,904.194	2.440	< 0.001	< 0.001
KRT6B	Keratin 6B	1172.249	6161.766	2.394	0.027	0.047
TUBB3	Tubulin, beta 3 class III	111.384	417.378	1.906	0.001	0.004
PLAU	Plasminogen activator,urokinase	2822.918	10,006.001	1.826	< 0.001	< 0.001
KRT7	Keratin 7	39,988.771	130,332.329	1.705	< 0.001	< 0.001
SLC5A6	Solute carrier family 5 member 6	1418.193	4135.391	1.544	< 0.001	< 0.001
KRT18	Keratin 18	19,330.929	55,592.157	1.524	< 0.001	< 0.001
Down
ACTC1	Actin alpha cardiac muscle 1	51,994.88	1794.546	− 4.857	< 0.001	< 0.001
FLNC	Filamin C	59,376.71	2885.509	− 4.363	< 0.001	< 0.001
MYH11	Myosin, heavy polypeptide 11	237,833.6	23,446.88	− 3.342	< 0.001	< 0.001
ANXA6	Annexin A6	26,066.21	4721.63	− 2.465	< 0.001	< 0.001
GSN	Gelsolin	96,941.96	20,053.63	− 2.273	< 0.001	< 0.001
HBA1	Hemoglobin subunit alpha 1	48.22997	10.420	− 2.211	< 0.001	< 0.001
ATP2B4	ATPase plasma membrane Ca2+ transporting 4	28,496.67	6309.244	− 2.175	< 0.001	< 0.001
HSPG2	Heparan sulfate proteoglycan 2	36,948.08	9688.238	− 1.931	0.005	0.011
THBS1	Thrombospondin 1	65,492.56	17,199.6	− 1.929	< 0.001	< 0.001
PYGB	Glycogen phosphorylase B	31,392.91	8562.172	− 1.874	0.002	0.005

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