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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation

Fig. 4

Inhibition of autophagy enhanced suppression of sorafenib on FLT3 downstream signaling and pro-apoptotic effect in both Ba/F3-ITD and Ba/F3-ITD + D835 mutated cells. A In Ba/F3-ITD cells, after autophagy was inhibited with CQ, sorafenib more markedly suppressed FLT3 downstream signaling of significantly induced cleaved caspase-3. B In Ba/F3-ITD + D835Y cells, without CQ co-treatment, sorafenib could only down-regulate the expression of p-FLT3, but not FLT3 downstream signaling, and no apparent cleaved caspase-3 was induced. After being dealt with CQ, autophagy was inhibited, sorafenib significantly suppressed the downstream signaling of FLT3 and up-regulated the expression of cleaved caspase-3

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Journal of Translational Medicine

ISSN: 1479-5876

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