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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Autophagy activation mediates resistance to FLT3 inhibitors in acute myeloid leukemia with FLT3-ITD mutation

Fig. 2

Sorafenib-resistant cell lines showed overpresentation of autophagy markers. A Baf/FLT3-ITD cell line was sensitive to sorafenib treatment with the apoptosis rate of 29.0 ± 3.1% at the concentration of 40 nM and 48.6 ± 2.9% at 80 nM. After acquiring D835Y mutation, Ba/F3-ITD + D835Y cell line showed resistant to sorafenib with the apoptosis rate of 10.5 ± 1.6% at the concentration of 100 nM and 14.3 ± 0.8% at 500 nM. B As being compared with Ba/F3-ITD cells, both Ba/F3-D835Y and Ba/F3-ITD + D835Y cells, which were resistant to sorafenib, showed increasing expression of LC3B-II (LC3B-II/I tatio: 1.0 in Ba/F3-ITD, 1.2 in Ba/F3-D835Y and 1.5 in Ba/F3-ITD + D835Y), Beclin-1 and ATG5, and decreasing p62

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Journal of Translational Medicine

ISSN: 1479-5876

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