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Table 3 ME/CFS and Long COVID Improvement in Physical and Mental Fatigue

From: Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial

ME/CFS % Fatigue Improvement From Baseline
500 mg BID N = 23 Overall Likert Score Overall Bimodal Score Treated % at or Below 4 on Bimodal Physical Fatigue Mental Fatigue
2-Weeks 18.1%* 25.0%*** 21.7%* 16.1%*** 19.4%***
6-Weeks 22.5%*** 23.7%*** 21.7%* 17.3%*** 17.5%***
1000 mg BID N = 29 Overall Likert Score Overall Bimodal Score Treated % at or Below 4 on Bimodal Physical Fatigue Mental Fatigue
2-Weeks 16.3%** 19.7%*** 17.1%* 18.7%*** 20.5%***
6-Weeks 27.9%*** 30.8%*** 27.6%*** 29.8%*** 25.9%***
1000 mg TID N = 24 Overall Likert Score Overall Bimodal Score Treated % at or Below 4 on Bimodal Physical Fatigue Mental Fatigue
2-Weeks 18.5%** 14.3%* 16.7%* 13.1%* 13.6%*
6-Weeks 23.3%*** 26.7%** 33.3%** 24.3%** 18.6%*
  Long COVID Improvement Over Baseline
Chalder Fatigue at 6 Weeks
2-Weeks 6-Weeks Physical Mental Bimodal 4 or Below
500 mg BID 34.6%*** 36%*** 33.5%*** 23.1%*** 46.8%*** 45.5%***
1000 mg BID 17.8%* 25.3%*** 15%* 2.60% 20.7%* 23.8%**
  1. *P < 0.05
  2. **P < 0.01
  3. ***P < 0.005