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Table 3 ME/CFS and Long COVID Improvement in Physical and Mental Fatigue

From: Oxaloacetate Treatment For Mental And Physical Fatigue In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long-COVID fatigue patients: a non-randomized controlled clinical trial

ME/CFS % Fatigue Improvement From Baseline

500 mg BID N = 23

Overall Likert Score

Overall Bimodal Score

Treated % at or Below 4 on Bimodal

Physical Fatigue

Mental Fatigue

2-Weeks

18.1%*

25.0%***

21.7%*

16.1%***

19.4%***

6-Weeks

22.5%***

23.7%***

21.7%*

17.3%***

17.5%***

1000 mg BID N = 29

Overall Likert Score

Overall Bimodal Score

Treated % at or Below 4 on Bimodal

Physical Fatigue

Mental Fatigue

2-Weeks

16.3%**

19.7%***

17.1%*

18.7%***

20.5%***

6-Weeks

27.9%***

30.8%***

27.6%***

29.8%***

25.9%***

1000 mg TID N = 24

Overall Likert Score

Overall Bimodal Score

Treated % at or Below 4 on Bimodal

Physical Fatigue

Mental Fatigue

2-Weeks

18.5%**

14.3%*

16.7%*

13.1%*

13.6%*

6-Weeks

23.3%***

26.7%**

33.3%**

24.3%**

18.6%*

 

Long COVID Improvement Over Baseline

Chalder Fatigue at 6 Weeks

2-Weeks

6-Weeks

Physical

Mental

Bimodal

4 or Below

500 mg BID

34.6%***

36%***

33.5%***

23.1%***

46.8%***

45.5%***

1000 mg BID

17.8%*

25.3%***

15%*

2.60%

20.7%*

23.8%**

  1. *P < 0.05
  2. **P < 0.01
  3. ***P < 0.005