Fig. 6
Differentially expressed and methylated genes were associated with weight loss, adipocyte size and neck circumference. A to C show the predicted probability (red dots from 0 to 1), obtained by binomial logistic regression, of each participant to have a complete (0) or a partial remission (1), based on %TWL, %adipocyte size and %neck circumference. OR is the odds ratio with 95% confidence intervals (CI) and P is the p value for the linear trend of association. Gray and blue dots refer BPD-DS and RYGB + SG, respectively. D to F respectively show associations between differentially expressed genes (DEGs) in each surgery group with the percentage of total weight loss (%TWL), adipocyte size change (%Adipocyte) and neck circumference change (%Neck). Green, blue and red dots respectively stand for associations at non-adjusted p < 0.05 with DEGs exclusive to BPD-DS, RYGB + SG or common to both surgery groups. Grey dots represent not significant associations. Dot size is proportional to the magnitude (r2) of the association. Results are from multivariate linear regression models adjusted for sex, age and BMI