Fig. 5

Genes being simultaneously differentially expressed and methylated largely belonged to the BPD-DS surgery group. A and B show respectively the proportion of differentially expressed genes (DEGs) down- and up-regulated that are simultaneously identified as differentially methylated genes (DMGs). The proportion of DEGs common to both surgery groups (COMMON), as well as exclusive to BPD-DS (BPD) and RYGB + SG (GAS) is shown in the inner ring. The proportion of hypermethylated and hypomethylated DMGs is shown in the outer ring. C and D show respectively the proportion of hypermethylated and hypomethylated CpG sites located within body or promoter regions of genes being simultaneously DEGs and DMGs. The proportion of genes being simultaneously DEGs and DMGs is shown in the inner ring, and the proportion of CpG sites for each gene location and surgery group is shown in the outer ring