Fig. 4

Immune-related pathways were markedly down-regulated following bariatric surgery. Left panel shows top Gene Ontology-Biological Process (GO-BP) terms significantly enriched with up-regulated (red blocks, up) and down-regulated (blue blocks, down) differentially expressed genes (DEGs). Right panel shows top GO-BP terms significantly enriched with hypermethylated (red blocks, up) and hypomethylated (blue blocks, down) differentially methylated genes (DMGs). Each column represents pathways enriched with DEGs specific to BPD-DS, RYGB + SG or common to both surgery groups. Pathways were considered significantly enriched when composed with at least 20 DEGs or DMGs and with FDR-adjusted p-value < 0.05