Fig. 3

Most of gene methylation changes in subcutaneous adipose tissue occur following BPD-DS. Panel A shows differentially methylated genes (DMGs) exclusive for BPD-DS (green dots) and common to both surgery groups (red dots). Panel B shows DMGs exclusive for RYGB-DS (blue dots) and common to both surgery groups (purple dots). DMGs were defined as loci with at least one differentially methylated CpG site (false discovery rate (FDR)-corrected p-value < 0.05 and fold change (FC) > 1.5. Panels C and D show density plots of FC distribution among hypermethylated and hypomethylated DMGs, respectively. Green and blue colors stand for DEGs exclusive for BPD-DS and RYGB + SG, respectively. Red and purple colors stand for DMGs common to both surgery groups but showing the specific FC distribution for each BPD-DS and RYGB + SG surgery, respectively. Dotted lines stand for mean FC values for each surgery