Fig. 2

Gene expression changes in subcutaneous adipose tissue were more pronounced following BPD-DS. Panel A shows differentially expressed genes (DEGs) exclusive for BPD-DS (green dots) and common to both surgery groups (red dots). Panel B shows DEGs exclusive for RYGB-DS (blue dots) and common to both surgery groups (purple dots). DEGs were considered significant when false discovery rate (FDR)-corrected p-value < 0.05 and fold change (FC) > 1.5. Panels C and D show density plots of FC distribution among down-regulated and up-regulated DEGs, respectively. Green and blue colors stand for DEGs exclusive for BPD-DS and RYGB + SG, respectively. Red and purple colors stand for DEGs common to both surgery groups but showing the specific FC distribution for each BPD-DS and RYGB + SG surgery, respectively. Dotted lines stand for mean FC values for each surgery group