Fig. 4

A, B The CD155 expression level in patients with cervical cancer was related to CD8⁺ T cell depletion. C Activated CD8⁺ T cells were treated with CD155-Fc. The ability of CD8⁺ T cells to secrete the cytokines IFN-γ, TNF-α and GranzymeB. D CD8⁺ T cells were stimulated with αCD3/CD28 and cocultured with tumour cells in the presence of an anti-TIGIT antibody, anti-PD-1 blocking antibody or isotype control. The production of IFN-γ, TNF-α and GranzymeB in CD8⁺ T cells was detected. The data are at least three independent experiments