Figure. 2

The level of CD8⁺TIGIT⁺ cells in patients with cervical cancer was related to CD8⁺ T cell depletion. A The proportion of CD8⁺TIGIT⁺ lymphocytes gradually increased in individuals with a normal cervix, patients with HSILs, and patients with cervical cancer. B The expression of TIGIT in CD8 + T cells was detected using mIHC. The level of CD8⁺TIGIT⁺ cells in cervical cancer tissues and adjacent tissues. C CD8⁺ T cells were isolated from PBMCs. The levels of TNF-α and IFN-γ secreted by CD8⁺TIGIT⁺ cells and CD8⁺TIGIT⁻ cells were detected by intracellular staining. The data are the mean ± SEM of the experiments. *P < 0.05, **P < 0.01