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Figure. 2 | Journal of Translational Medicine

Figure. 2

From: Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer

Figure. 2

The level of CD8+TIGIT+ cells in patients with cervical cancer was related to CD8+ T cell depletion. A The proportion of CD8+TIGIT+ lymphocytes gradually increased in individuals with a normal cervix, patients with HSILs, and patients with cervical cancer. B The expression of TIGIT in CD8 + T cells was detected using mIHC. The level of CD8+TIGIT+ cells in cervical cancer tissues and adjacent tissues. C CD8+ T cells were isolated from PBMCs. The levels of TNF-α and IFN-γ secreted by CD8+TIGIT+ cells and CD8+TIGIT cells were detected by intracellular staining. The data are the mean ± SEM of the experiments. *P < 0.05, **P < 0.01

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