Fig. 2

The 9 core MicT/MicN genes in glioma biology. A the performance of core genes in glioma Tumor/Normal, Recurrence/Primary, and High-risk/low-risk conditions. B An example for MMP19 gene from consistent signatures in GSE50161, GSE101113 and GSE83300. C the correlation map of core genes and tumor purity from four methods (Estimate, Lump, Ihc and CPE). The outside circle indicated GBM results and inside circle indicated LGG results. Red indicated positive correlation and blue indicated negative correlation. And star indicated significant results with FDR < 0.05. D The 5 genes with significantly positive and negative correlation were shown. And the prognostic performance of these genes in samples with high purity and low purity from CPE method were further evaluated. Red star indicated risk factors and blue star indicated protective factors. *0.05–0.01, **0.001–0.01, ***< 0.0001. The detailed survival results were displayed for P2RY2 gene. E The expression levels of P2RY2 signature in samples with different treatment results, PD: Progression Disease, SD: Stable Disease, PR: Partial Response, CR: Complete Response. F The associations between P2RY2 expression level and tumor characterization, including Wound healing, Indel neoantigens and Aneuploidy for both GBM and LGG types