Fig. 6

Treatment with eFT-508 leads to significant downregulation of PD-L1 and PD-L2. CyTOF (viSNE plots) analysis of PD-L1 and PD-L2 expression in tumor tissue obtained from xenograft mice (as described in Fig. 4) injected with either vehicle (A), adriamycin (B), eFT-508 (C), or adriamycin + eFT-508 (D). E Quantification of data shown in A–D. Data are represented as mean ± standard deviation; *P < 0.05, ****P < 0.0001, ns—not significant (P > 0.05) (n = 5 mice/group)