Fig. 2

Computational pathology workflow. A The classification model to differentiate between cholangiocarcinoma and PAC was built through tumor region annotation in WSIs, color normalization, and feature extraction. B Through by similar steps, the features extracted from a WSI of pancreatobiliary-type AAC were input to the classification model to infer the tumor origin. AAC, ampullary adenocarcinoma; CHOL, cholangiocarcinoma; PAC, pancreatic adenocarcinoma; PB, pancreatobiliary; WSI, whole-slide image