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Table 5 The odd ratios of treatments for patients with and without chronic fatigue syndrome in difference subgroup of sex

From: Treatments of chronic fatigue syndrome and its debilitating comorbidities: a 12-year population-based study

Variable Control
(n = 6306)
CFS
(n = 6306)
Odds ratio
Female Crude (95% CI) p-value Adjusted (95% CI) p-value
No Yes No Yes
SSRI      2.36 (1.99,2.81)*** < 0.001 1.71 (1.42,2.06)*** < 0.001
 No 2815 3131 2639 2886     
 Yes 152 208 328 453     
SNRI      2.04 (1.51,2.75)*** < 0.001 1.42 (1.04,1.95)* 0.029
 No 2922 3273 2858 3207     
 Yes 45 66 109 132     
SARI      2.10 (1.77,2.5)*** < 0.001 1.46 (1.21,1.76)*** < 0.001
 No 2805 3122 2611 2913     
 Yes 162 217 356 426     
TCAs      2.25 (1.62,3.13)*** < 0.001 1.69 (1.2,2.38)** 0.003
 No 2911 3286 2891 3222     
 Yes 56 53 76 117     
BZD      2.22 (2.01,2.46)*** < 0.001 1.71 (1.53,1.92)*** < 0.001
 No 1663 1597 1133 975     
 Yes 1304 1742 1834 2364     
NDRI      2.16 (1.28,3.63)** 0.004 1.39 (0.8,2.4) 0.241
 No 2948 3318 2916 3294     
 Yes 19 21 51 45     
Muscle relaxant      1.89 (1.45,2.45)*** < 0.001 1.52 (1.15,2.01)** 0.003
 No 2889 3250 2836 3175     
 Yes 78 89 131 164     
Analgesic drug      13.54 (9.80,18.7)*** < 0.001 10.11 (7.26,14.09)*** < 0.001
 No 590 481 61 41     
 Yes 2377 2858 2906 3298     
Supportive individual psychotherapy      1.74 (1.42,2.13)*** < 0.001 1.19 (0.96,1.48) 0.121
 No 2851 3181 2731 3074     
 Yes 116 158 236 265     
Intensive individual psychotherapy      4.03 (1.85,8.76)*** < 0.001 2.76 (1.21,6.3)* 0.016
 No 2961 3331 2944 3307     
 Yes 6 8 23 32     
Re-educative individual psychotherapy     1.98 (1.61,2.44)*** < 0.001 1.26 (1.01,1.59)* 0.045
 No 2860 3197 2755 3069     
 Yes 107 142 212 270     
Stretching exercise      1.49 (1.26,1.77)*** < 0.001 1.30 (1.09,1.56)** 0.004
 No 2787 3097 2726 2990     
 Yes 180 242 241 349     
Therapeutic exercise      1.39 (1.22,1.59)*** < 0.001 1.24 (1.07,1.43)** 0.003
 No 2637 2898 2477 2756     
 Yes 330 441 490 583     
Brainwave examination, sleep or wakefulness     1.42 (0.99,2.04) 0.057 1.18 (0.81,1.74) 0.393
 No 2886 3288 2902 3267     
 Yes 81 51 65 72     
Variable Control
(n = 6306)
CFS
(n = 6306)
Odds ratio
Male Crude (95% CI) p-value Adjusted (95% CI) p-value
No Yes No Yes
SSRI      2.3 (1.89,2.81)*** < 0.001 1.70 (1.37,2.10)*** < 0.001
 No 3131 2815 2886 2639     
 Yes 208 152 453 328     
SNRI      2.48 (1.74,3.52)*** < 0.001 1.64 (1.13,2.38)** 0.009
 No 3273 2922 3207 2858     
 Yes 66 45 132 109     
SARI      2.36 (1.95,2.86)*** < 0.001 1.71 (1.38,2.10)*** < 0.001
 No 3122 2805 2913 2611     
 Yes 217 162 426 356     
TCAs      1.37 (0.96,1.94) 0.079 1.06 (0.73,1.53) 0.771
 No 3286 2911 3222 2891     
 Yes 53 56 117 76     
BZD      2.06 (1.86,2.29)*** < 0.001 1.69 (1.50,1.90)*** < 0.001
 No 1597 1663 975 1133     
 Yes 1742 1304 2364 1834     
NDRI      2.71 (1.60,4.61)*** < 0.001 1.81 (1.03,3.17)* 0.039
 No 3318 2948 3294 2916     
 Yes 21 19 45 51     
Muscle relaxant      1.71 (1.29,2.28)*** < 0.001 1.53 (1.13,2.07)** 0.005
 No 3250 2889 3175 2836     
 Yes 89 78 164 131     
Analgesic drug      11.82 (9.03,15.47)*** < 0.001 9.40 (7.11,12.43)*** < 0.001
 No 481 590 41 61     
 Yes 2858 2377 3298 2906     
Supportive individual psychotherapy      2.12 (1.69,2.67)*** < 0.001 1.38 (1.08,1.77)* 0.012
 No 3181 2851 3074 2731     
 Yes 158 116 265 236     
Intensive individual psychotherapy      3.86 (1.57,9.48)** 0.003 2.56 (1.00,6.57) 0.051
 No 3331 2961 3307 2944     
 Yes 8 6 32 23     
Re-educative individual psychotherapy     2.06 (1.62,2.61)*** < 0.001 1.39 (1.07,1.80)* 0.014
 No 3197 2860 3069 2755     
 Yes 142 107 270 212     
Stretching exercise      1.37 (1.12,1.67)** 0.002 1.21 (0.98,1.49) 0.081
 No 3097 2787 2990 2726     
 Yes 242 180 349 241     
Therapeutic exercise      1.58 (1.36,1.84)*** < 0.001 1.44 (1.23,1.69)*** < 0.001
 No 2898 2637 2756 2477     
 Yes 441 330 583 490     
Brainwave examination, sleep or wakefulness     0.8 (0.57,1.11) 0.181 0.75 (0.53,1.07) 0.117
 No 3288 2886 3267 2902     
 Yes 51 81 72 65     
  1. CFS: chronic fatigue syndrome; CI: confidence interval;*P < .05, **P < .01, ***P < .001