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Table 5 The odd ratios of treatments for patients with and without chronic fatigue syndrome in difference subgroup of sex

From: Treatments of chronic fatigue syndrome and its debilitating comorbidities: a 12-year population-based study

Variable

Control

(n = 6306)

CFS

(n = 6306)

Odds ratio

Female

Crude (95% CI)

p-value

Adjusted (95% CI)

p-value

No

Yes

No

Yes

SSRI

    

2.36 (1.99,2.81)***

< 0.001

1.71 (1.42,2.06)***

< 0.001

 No

2815

3131

2639

2886

    

 Yes

152

208

328

453

    

SNRI

    

2.04 (1.51,2.75)***

< 0.001

1.42 (1.04,1.95)*

0.029

 No

2922

3273

2858

3207

    

 Yes

45

66

109

132

    

SARI

    

2.10 (1.77,2.5)***

< 0.001

1.46 (1.21,1.76)***

< 0.001

 No

2805

3122

2611

2913

    

 Yes

162

217

356

426

    

TCAs

    

2.25 (1.62,3.13)***

< 0.001

1.69 (1.2,2.38)**

0.003

 No

2911

3286

2891

3222

    

 Yes

56

53

76

117

    

BZD

    

2.22 (2.01,2.46)***

< 0.001

1.71 (1.53,1.92)***

< 0.001

 No

1663

1597

1133

975

    

 Yes

1304

1742

1834

2364

    

NDRI

    

2.16 (1.28,3.63)**

0.004

1.39 (0.8,2.4)

0.241

 No

2948

3318

2916

3294

    

 Yes

19

21

51

45

    

Muscle relaxant

    

1.89 (1.45,2.45)***

< 0.001

1.52 (1.15,2.01)**

0.003

 No

2889

3250

2836

3175

    

 Yes

78

89

131

164

    

Analgesic drug

    

13.54 (9.80,18.7)***

< 0.001

10.11 (7.26,14.09)***

< 0.001

 No

590

481

61

41

    

 Yes

2377

2858

2906

3298

    

Supportive individual psychotherapy

    

1.74 (1.42,2.13)***

< 0.001

1.19 (0.96,1.48)

0.121

 No

2851

3181

2731

3074

    

 Yes

116

158

236

265

    

Intensive individual psychotherapy

    

4.03 (1.85,8.76)***

< 0.001

2.76 (1.21,6.3)*

0.016

 No

2961

3331

2944

3307

    

 Yes

6

8

23

32

    

Re-educative individual psychotherapy

   

1.98 (1.61,2.44)***

< 0.001

1.26 (1.01,1.59)*

0.045

 No

2860

3197

2755

3069

    

 Yes

107

142

212

270

    

Stretching exercise

    

1.49 (1.26,1.77)***

< 0.001

1.30 (1.09,1.56)**

0.004

 No

2787

3097

2726

2990

    

 Yes

180

242

241

349

    

Therapeutic exercise

    

1.39 (1.22,1.59)***

< 0.001

1.24 (1.07,1.43)**

0.003

 No

2637

2898

2477

2756

    

 Yes

330

441

490

583

    

Brainwave examination, sleep or wakefulness

   

1.42 (0.99,2.04)

0.057

1.18 (0.81,1.74)

0.393

 No

2886

3288

2902

3267

    

 Yes

81

51

65

72

    

Variable

Control

(n = 6306)

CFS

(n = 6306)

Odds ratio

Male

Crude (95% CI)

p-value

Adjusted (95% CI)

p-value

No

Yes

No

Yes

SSRI

    

2.3 (1.89,2.81)***

< 0.001

1.70 (1.37,2.10)***

< 0.001

 No

3131

2815

2886

2639

    

 Yes

208

152

453

328

    

SNRI

    

2.48 (1.74,3.52)***

< 0.001

1.64 (1.13,2.38)**

0.009

 No

3273

2922

3207

2858

    

 Yes

66

45

132

109

    

SARI

    

2.36 (1.95,2.86)***

< 0.001

1.71 (1.38,2.10)***

< 0.001

 No

3122

2805

2913

2611

    

 Yes

217

162

426

356

    

TCAs

    

1.37 (0.96,1.94)

0.079

1.06 (0.73,1.53)

0.771

 No

3286

2911

3222

2891

    

 Yes

53

56

117

76

    

BZD

    

2.06 (1.86,2.29)***

< 0.001

1.69 (1.50,1.90)***

< 0.001

 No

1597

1663

975

1133

    

 Yes

1742

1304

2364

1834

    

NDRI

    

2.71 (1.60,4.61)***

< 0.001

1.81 (1.03,3.17)*

0.039

 No

3318

2948

3294

2916

    

 Yes

21

19

45

51

    

Muscle relaxant

    

1.71 (1.29,2.28)***

< 0.001

1.53 (1.13,2.07)**

0.005

 No

3250

2889

3175

2836

    

 Yes

89

78

164

131

    

Analgesic drug

    

11.82 (9.03,15.47)***

< 0.001

9.40 (7.11,12.43)***

< 0.001

 No

481

590

41

61

    

 Yes

2858

2377

3298

2906

    

Supportive individual psychotherapy

    

2.12 (1.69,2.67)***

< 0.001

1.38 (1.08,1.77)*

0.012

 No

3181

2851

3074

2731

    

 Yes

158

116

265

236

    

Intensive individual psychotherapy

    

3.86 (1.57,9.48)**

0.003

2.56 (1.00,6.57)

0.051

 No

3331

2961

3307

2944

    

 Yes

8

6

32

23

    

Re-educative individual psychotherapy

   

2.06 (1.62,2.61)***

< 0.001

1.39 (1.07,1.80)*

0.014

 No

3197

2860

3069

2755

    

 Yes

142

107

270

212

    

Stretching exercise

    

1.37 (1.12,1.67)**

0.002

1.21 (0.98,1.49)

0.081

 No

3097

2787

2990

2726

    

 Yes

242

180

349

241

    

Therapeutic exercise

    

1.58 (1.36,1.84)***

< 0.001

1.44 (1.23,1.69)***

< 0.001

 No

2898

2637

2756

2477

    

 Yes

441

330

583

490

    

Brainwave examination, sleep or wakefulness

   

0.8 (0.57,1.11)

0.181

0.75 (0.53,1.07)

0.117

 No

3288

2886

3267

2902

    

 Yes

51

81

72

65

    
  1. CFS: chronic fatigue syndrome; CI: confidence interval;*P < .05, **P < .01, ***P < .001