Fig. 5

Drug, cell line, and TME analysis. A Radar plot showing the correlation between the CSGPI score and mismatch repair genes and methyltransferases; B comparison between the metastasis and no metastasis groups concerning immune checkpoint genes; C Kaplan–Meier curve of metastasis-free survival for CD226; D radar plot showing the correlation between the CSGPI score and immune checkpoint genes; E comparison between the metastasis and no metastasis groups for TME parameters; F radar plot showing the correlation between the CSGPI score and TME parameters; G comparison between the ≥ 65 and < 65 groups for TME parameters; H radar plot showing the correlation between age and TME parameters; I upset plot of commonly sensitive drugs of ALCAM and ALDH2; B upset plot of common cell lines of ALCAM, ALDH2, and sensitive drugs. GDSC genomics of drug sensitivity in cancer; CTRP the cancer therapeutics response portal; TME tumor immune microenvironment; CSGPI cellular senescence-related gene prognostic index