A dPCR-NIPT assay for detections of trisomies 21, 18 and 13 in a single-tube reaction-could it replace serum biochemical tests as a primary maternal plasma screening tool?

Table 4 Calling algorithm for sample test results

The calling algorithm for sample test results: the top half portion tabulates the "aneuploidy risk” calls for Z_21/18, Z_21/13 and Z_18/13 of a testing sample, and the lower half portion demonstrates 11 possible scenarios of combined 3 Z-score calls for a sample's test results and the final conclusion for the sample's aneuploidy status
*For Scenario 11, if there are any 2 conflict trisomic calls (for example, Z_21/18 calls T21 and Z_18/13 calls T13) for a sample, this sample must be re-tested: (1) if re-test results fall into one of the first 10 scenarios, this sample’s final result should be call according to that scenario; (2) if re-test results fall into Scenario 11 again regardless of any two conflict calls, this sample’s final result should be a no-call

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