A dPCR-NIPT assay for detections of trisomies 21, 18 and 13 in a single-tube reaction-could it replace serum biochemical tests as a primary maternal plasma screening tool?

Table 3 cffDNA fraction and cfDNA concentration information

Categorized by	Number	cffDNA(%)			cfDNA(ng/uL)
Categorized by	Number	Mean	Median	Range	Mean	Median	Range
Mat. age (Years)
≤ 24	32	13.40	13.24	6.41–21.03	0.35	0.33	0.22–0.72
25–34	194	12.10	11.21	3.10–34.64	0.36	0.34	0.20–0.71
≥ 35	57	10.95	9.57	3.72–26.22	0.36	0.35	0.24–0.87
Gest. age (Weeks)
12–15	55	11.43	10.28	4.09–28.59	0.37	0.35	0.20–0.71
16–20	199	11.89	11.26	3.10–31.21	0.36	0.35	0.22–0.87
21–25	17	11.94	10.87	4.87–21.24	0.32	0.31	0.20–0.50
≥ 26	12	18.88	17.79	4.62–34.64	0.41	0.37	0.23–0.72
Total	283	11.97	11.06	3.10–34.64	0.36	0.34	0.20–0.87

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