Fig. 6

ROC curve analysis to assess the performance of the dPCR-NIPT assay over a range of Z-score cut-off values, both in a trisomy-specific manner and in a manner of combining all three trisomies as one screening test. The absolute value of a Z-score was used as a predictor of trisomies for samples exceeding the cut-off value of 1.65 for the number of high risk results. Panels A–D show the results of the T21, T18, T13, and the combined test, respectively, and the corresponding AUC value for each test is presented in each panel