Fig. 3

CCL20 and CCL24 involved in crizotinib resistance. A 10 chemokines mRNA expression in H3122CR compared with H3122 (Control); B 4 chemokines protein expression in H3122 and H3122CR cell supernatants; C The mRNA and protein expression of 4 chemokines after si-RNA treatment compared with si-negative control (si-NC); D–F Effect of CCL2, CCL20, CCL24, and CX3CL1 knockdown on (D) cell proliferation of H3122CR; (E) cell cycle distribution of H3122CR; F half maximal inhibitory concentration (IC50) of crizotinib in H3122CR. * p < 0.05, ** p < 0.01, *** p < 0.001, ns: not significant