Fig. 4

Protein hits and their assigned co-abundance cluster for each considered biological process. Depending on the measured intensities at different time points of the experiment (Baseline, ALS, CARL), the identified proteins were assigned to different co-abundance cluster with a confidence interval of 95%. Cluster assignment was performed by using the Clust algorithm and assigned proteins were manually annotated to one of the respective biological processes: a hemolysis, b coagulation, c inflammation, d cell death. Each line represents an individual protein, while y-axis illustrates the relative abundance change after Z-score normalization. Bold protein names represent proteins that already showed a significant abundance change (adjusted p-value ≤ 0.05) during to the previous differential expression analysis (Fig. 3) for at least one of the considered comparisons. The number of assigned proteins per cluster is shown above each graph