Table 2 The activating receptors of NK cells
From: Natural killer cells: a promising immunotherapy for cancer
Receptors | CD | Structure | Ligand | Signal molecule | Chromosome |
|---|---|---|---|---|---|
2B4 | CD224 | Ig monomer | CD48 | ITSM, SAP | 1q23.1 [107] |
KIR2DS1 | CD158h | Ig monomer | HLA-C, N77/N80 | DAP12 | 19q13.4 [97] |
KIR2DS2 | CD158j | Ig monomer | Unknown | DAP12 | 19q13.4 [111] |
KIR2DS4 | CD158i | Ig monomer | HLA-Cw4 | DAP12 | 19q13.4 [66] |
KIR3DS1 | CD158e2 | Ig monomer | Unknown | DAP12 | 19q13.4 [112] |
KIR2DL4 | CD158d | Ig monomer | HLA-G | FcεRIγ | 19q13.4 [113] |
NKp46(NCR1) | CD335 | Ig monomer | HV | FcεRIγ, CD3ζ | 19q13.4 [78] |
NKp44(NCR2) | CD336 | Ig monomer | HV | DAP12 | 6p21.1 [100] |
NKp30(NCR3) | CD337 | Ig monomer | Pp65, BAT-3, B7-H6 | FcεRIγ, CD3ζ | 6p21.3 [100] |
FCGR3(FcγRIII) | CD16 | Ig monomer | IgG | FcεRIγ, CD3ζ | 1q23 [114] |
DNAM-1 | CD226 | Ig monomer | CD112, CD155 | Protein kinase C | 18q22.3 [115] |
SLAMF7 | CD319 | Ig monomer | CRACC | ITSM, EAT2 | 1q23.1–4 [116] |
SLAMF6 | No | Ig monomer | NBT-A | ITSM | 1q23.2 [117] |
TACTILE | CD96 | Ig monomer | CD112, CD155 | Unknown | 3q13-q12.2 [118] |
CD27 | CD27 | Ig monomer | CD70 | TRAF2, TRAF5, SIVA | 12p13 [119] |
CD94-NKG2C(KLRD1-KLRC2) | CD159c | C lectin heterodimer | HLA-E | DAP12 | 12p13 [120] |
CD94-NKG2E | No | C lectin heterodimer | HLA-E | DAP12 | 12p13 [120] |
NKG2D(KLRK1) | CD314 | C lectin heterodimer | ULBP1-4, MICA/B | DAP10 | 12p13 [87] |
NKp80(KLRF1) | No | C lectin heterodimer | AICL | Unknown | 12p13.2-p12.3 [79] |