Fig. 6
From: mTOR pathway gene mutations predict response to immune checkpoint inhibitors in multiple cancers
mTOR pathway mutations and pathway enrichment analysis. Pathway enrichment analysis from TCGA database using GSEA method, in the comparison of mutant-type versus wild-type patients for the 8-gene signature involved in mTOR pathway. We showed representative pathway enrichment involved in immunity, DNA repair, and protein folding (A). All pathways enriched was summarized in one figure (B). Our association analysis of survival, immune phenotype, and potential mechanisms demonstrated the switch from immunologically “cold” to “hot” microenvironment in tumors in presence of the 8-gene signature involved in mTOR pathway (C)