Fig. 6
From: Single-cell landscape of immunocytes in patients with extrahepatic cholangiocarcinoma
Intercellular cross-talk between immune cells in ECCA. Dot plots present selected ligand–receptor cross-linkages between two immune clusters for Tregs, the exhausted CD8 + T lymphocytes C1-CD8/C4-CD8 and the M2 macrophages C6-Mye. The significant means of the expression levels of two interacting molecules are shown by a color heatmap (right panel), with light blue to green representing low to high expression. The P values from a one-sided permutation test are shown by circle size. Different colors of squares on the left side indicate different functional factors involved in receptor–ligand crosstalk