Fig. 6From: SIRT1 prevents cigarette smoking-induced lung fibroblasts activation by regulating mitochondrial oxidative stress and lipid metabolismTargeting mtROS or SIRT1 regulated NOX4, SOD2, PPARα and CPT1a of LF in vivo. Mice exposed to CS were treated with MitoQ or SRT1720 at the start of smoking. 4 weeks later, lungs were harvested. A–C The expression of collagen I in lungs was examined by immunohistochemistry and CPT1a, PPARα, SIRT1, NOX4 and SOD2 level in LF (collagen I-positive cells) were detected by immunofluorescence. D CS decreased SIRT1 to activate LF by promoting mitochondrial oxidative stress, which dysregulated FAO and mitophagy through impairing autophagy flux. CS cigarette smokingBack to article page