Fig. 2
From: Inhibition of NOS1 promotes the interferon response of melanoma cells
NOS1 deletion disturbed multiple metabolic pathways in melanoma cells. A Volcano plot of the transcriptional data. X- axis: log2FC, Y-axis: –log10 (p-value). Red: upregulated gene, blue: downregulated gene. B KEGG analysis displays the up and down pathways (top ten) of NOS1-KO differential expression genes. X-axis: the number of enriched gene, Y-axis: KEGG pathway. C CLUE GO analysis indicated the metabolic pathways enriched genes are involved in macr omolecules biosynthesis. D The schematic diagram of DEGs in urea cycle. Red: upregulated gene, Green: downregulated gene. E GSEA showed JAK-STAT signaling pathway up-regulated by NOS1 deletion. F qPCR validated the expression of 12 genes in JAK-STAT signal