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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: CDK4/6 inhibitors sensitize gammaherpesvirus-infected tumor cells to T-cell killing by enhancing expression of immune surface molecules

Fig. 3

CDK4/6 inhibitors increase cell surface expression of ICAM-1, B7-2, and PD-L1 in KSHV- and EBV- uninfected and infected cells. BJAB, JSC-1, BCBL-1, BC-1, BC-2, Akata, Raji, and Daudi cells were treated with 1 μM Abe, 1 μM Pal, 5 μM Rib, or RPMI medium control for 72 h. HUVEC and HUVEC.BAC16 cells were treated with 0.5 μM Abe, 0.5 μM Pal, 2.5 μM Rib, or EGM-2 medium control for 4 days. Surface expression of ICAM-1, B7-2 and PD-L for the lymphoma cells (ac) and endothelial cells (df) were analyzed by flow cytometry. Results shown are mean fold changes relative to untreated cells from 3 experiments. Statistics were done using unpaired two-tailed t-test. Asterisks indicate p values: *p < 0.05, **p < 0.01, ***p < 0.001

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