Fig. 8

circMAP3K4 regulates PTPN1 expression through miR-6795-5p. A PTPN1 mRNA expression in HTR-8/SVneo cells in the different groups as determined by qPCR. B Western blot analysis of PTPN1 protein expression in different groups of HTR-8/SVneo cells, the representative images were displayed. C circMAP3K4 acts as a sponge of miR-6795-5p to modulate insulin resistance (IR) in trophoblast cells by regulating PTPN1 expression. The cell experiment was repeated three times. *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significant difference