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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: TPI1 activates the PI3K/AKT/mTOR signaling pathway to induce breast cancer progression by stabilizing CDCA5

Fig. 5

CDCA5 is essential for TPI1-mediated proliferation, EMT and aerobic glycolysis. A Overexpressing CDCA5 reversed reduction of proliferation owing to stably silencing TPI1 in T47D cells. B, C Rescue assays for migration (B) and wound healing (C) were performed after overexpressing CDCA5 in T47D/shTPI1 cells. D, E Rescue assays for glucose uptake (D) and lactate production (E) in indicated cells. F Western blot analysis of AKT, p-AKT, mTOR, p-mTOR, EMT markers, and LDHA expression in T47D/shTPI1 treated with or without overexpression of CDCA5. β-Actin served as a control (**p < 0.01, ***p < 0.001, ****p < 0.0001)

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Journal of Translational Medicine

ISSN: 1479-5876

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