Fig. 3

DEPTH2 ITH correlating positively with genomic instability in cancer. A DEPTH2 scores having significant positive correlations with tumor mutation burden (TMB) and copy number alteration (CNA) scores in multiple cancer types. The Spearman correlation coefficients (ρ) and P values are shown. TMB: the total somatic mutation count in the tumor. B DEPTH2 scores are significantly higher in TP53-mutated than in TP53-wildtype tumors in 14 cancer types (one-tailed Mann–Whitney U test, P < 0.05). C DEPTH2 scores having significant positive correlations with the expression of DNA mismatch repair proteins (MSH2, MSH6, and PCNA) in diverse cancers. D DEPTH2 scores having significant positive correlations with homologous recombination deficiency (HRD) scores in diverse cancers (Spearman correlation, P < 0.05). *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant