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Table 2 Baseline characteristics of study participants and non-responders by common SNPs of GCKR genotypes

From: Evaluating machine learning-powered classification algorithms which utilize variants in the GCKR gene to predict metabolic syndrome: Tehran Cardio-metabolic Genetics Study

Variables Male Female
Responders (%) Non-Responders (%) P value Responders (%) Non-Responders (%) P value
Group size (%) 2164 (72.28) 830 (27.72)   2590 (68.28) 1203 (31.72)  
Age(mean ± SD) 39.35 ± 14.59 41.48 ± 15.31 0.06141 36.25 ± 11.51 37.06 ± 14.6 0.0649a
Schooling years (mean ± SD) 10.02 ± 4.65 9.91 ± 4.4 0.5821 9.58 ± 4.4 9.32 ± 4.36 0.145a
BMI (mean ± SD) 24.86 ± 3.87 25.12 ± 4.38 0.02461 26.31 ± 4.68 26.63 ± 4.92 0.0539a
Physical activity (mean ± SD) 607.79 ± 1049.11 524.49 ± 1034.92 0.05101 429.78 ± 696.21 384.48 ± 682.76 0.0607a
Smoking status (%)
 Never smoker 825 (38.12) 283 (34.10) 0.2212 1732 (66.87) 717 (59.60) 0.002b
 Former smoker 219 (10.12) 88 (10.60) 8 (0.31) 13 (1.08)
 Current smoker 547(25.28) 196 (23.61) 59 (2.28) 35 (2.91)
 Second hand 573(26.48) 171 (20.60) 791 (30.54) 371 (30.84)
Marital status (%)
 Divorced 12 (0.55) 1(0.05) 0.1042 33 (1.27) 18 (1.50)  < 0.001b
 Married 1628 (75.23) 649(29.99) 2011 (77.64) 954 (79.30)
 Single 520 (24.03) 176 (8.13) 462 (17.84) 155 (12.88)
 Widowed 4 (0.18) 3 (0.14) 84 (3.24) 76 (6.32)
rs1260326 (%)
 CC 662 (30.59) 265 (31.93) 0.2332 755 (29.15) 370 (30.76) 0.602b
 TC 1015 (46.90) 402 (48.43) 1265 (48.84) 574 (47.71)
 TT 487 (22.50) 163 (49.64) 570 (22.01) 259 (21.53)
rs780094 (%)
 CC 676 (31.24) 251 (30.24) 0.302 773 (28.30) 358 (29.76) 0.998b
 TC 1015 (46.90) 414 (49.88) 1256 (48.49) 584 (48.55)
 TT 473 (21.86) 165 (19.88) 561 (21.66) 261 (21.70)
rs780093 (%)
 CC 672 (31.05) 179 (21.57) 0.1762 754 (29.11) 280 (23.28) 0.087b
 TC 1010 (46.67) 315 (37.95) 1275 (49.23) 404 (33.58)
 TT 482 (22.27) 125 (15.06) 561 (21.66) 214 (17.79)
  1. BMI Body Mass Index; There were no significant differences between responders and non-responders in males and females other than higher BMI and lower physical activity in male non-responders and different smoking and marital status distribution between female responders and non-responders
  2. aStudent's t-test
  3. bchi-square test