Table 2 Performance of the 90-gene expression assay in 21 tumor types
Tumor types | Number | Agreement | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
Adrenal | 31 | 31 | 100.0% | 100.0% | 100.0% | 100.0% |
Brain | 46 | 44 | 95.7% | 99.9% | 97.8% | 99.9% |
Breast | 123 | 121 | 98.4% | 99.8% | 98.4% | 99.8% |
Cervix | 93 | 89 | 95.7% | 99.0% | 87.3% | 99.7% |
Colorectum | 114 | 107 | 93.9% | 99.8% | 97.3% | 99.5% |
Endometrium | 79 | 77 | 97.5% | 99.6% | 93.9% | 99.9% |
Gastroesophagus | 106 | 96 | 90.6% | 99.0% | 88.1% | 99.2% |
Germ cell | 40 | 39 | 97.5% | 99.5% | 84.8% | 99.9% |
Head&neck | 31 | 23 | 74.2% | 99.9% | 92.0% | 99.4% |
Kidney | 64 | 62 | 96.9% | 100.0% | 100.0% | 99.9% |
Liver | 84 | 76 | 90.5% | 99.8% | 97.4% | 99.4% |
Lung | 141 | 134 | 95.0% | 99.8% | 98.5% | 99.5% |
Melanoma | 54 | 48 | 88.9% | 100.0% | 100.0% | 99.6% |
Mesothelioma | 12 | 12 | 100.0% | 99.3% | 54.5% | 100.0% |
Neuroendocrine | 52 | 49 | 94.2% | 99.7% | 92.5% | 99.8% |
Ovary | 54 | 51 | 94.4% | 99.4% | 86.4% | 99.8% |
Pancreas | 45 | 40 | 88.9% | 99.9% | 97.6% | 99.6% |
Prostate | 51 | 51 | 100.0% | 99.9% | 98.1% | 100.0% |
Sarcoma | 46 | 43 | 93.5% | 99.8% | 93.5% | 99.8% |
Thyroid | 96 | 92 | 95.8% | 100.0% | 100.0% | 99.7% |
Urinary | 55 | 53 | 96.4% | 99.9% | 96.4% | 99.9% |
Total | 1417 | 1338 | Accuracy = 94.4% | |||