Fig. 1
From: Activation of miR-500a-3p/CDK6 axis suppresses aerobic glycolysis and colorectal cancer progression
miR-500a-3p is down regulated in CRC and its low expression predicts poor prognosis. A The enrichment of miR-500a-3p was determined in normal human colon epithelial cell line NCM460 and six CRC cell lines by RT-qPCR. B The expression of miR-500a-3p was detected by qPCR in 20 pairs of CRC tissues. C, D The Kaplan–Meier survival curves of overall survival (C) and disease-free survival (D) in the cohort which contained 134 continuous CRC specimens. Patients were divided into two groups according to the expression of miR-500a-3p. Median expression levels were used as the cutoff. E Representative images of ki67 IHC staining (left) and quantification data (right) were shown. Scale bar, 100 μm. F The association between miR‐500a‐3p mRNA level and glucose uptake in 52 patients receiving PETCT preoperatively (Spearman’s correlation analysis). Glucose uptake was represented by Standard Uptake Value of PET-CT. The left pictures showed the PET-CT images of the patients indicated by the red dot. *P < 0.05, **P < 0.01, ***P < 0.001