Fig. 6

AdipoRon inhibits subcutaneous NPC-xenograft growth. A, D The tumor-bearing mice were euthanized at the end of the experiment and the subcutaneous NPC tumors were dissected and photographed. B, E Average tumor weight of CNE-2 (n = 6 per group) and 5-8F (n = 8 per group) derived xenograft tumors at the end of treatment with vehicle or AdipoRon. C, F The growth curves of the subcutaneous tumors. G Hematoxylin–eosin and IHC staining of Ki-67, and CD31 in the subcutaneous tumors derived from CNE-2 and 5-8F cells following the treatment with vehicle or AdipoRon. Bars: 100 μm. Quantification of Ki-67 positive cells (H) and vessel density (I) in the collected tumor tissues (n = 6 per group). Results are presented as mean ± SD of three independent experiments performed in triplicate. *P < 0.05, **P < 0.01, ***P < 0.001, ^#P < 0.0001