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Table 2 Univariate and multivariate analyses of factors associated with survival and cancer-free survival

From: IRF-2 inhibits cancer proliferation by promoting AMER-1 transcription in human gastric cancer

  OS DFS
Hazard ratio (95%CI) P value Hazard ratio (95%CI) P value
Univariate analyses
 Sex (male vs female) 0.875 (0.417, 1.836) 0.725 1.016 (0.484, 2.131) 0.967
 Age, y (< 60 vs. ≥ 60) 1.088 (0.800, 1.480) 0.589 1.050 (0.772, 1.427) 0.756
 Histological grade (G1-2 vs. G3) 1.871 (0.980, 3.573) 0.058 1.883 (0.985,3.600) 0.055
 Invasive depth (mucosa to muscularis propria vs. adventitia to adjacent structure) 0.434 (0.259, 0.728) 0.002 0.405 (0.241, 0.680) 0.001
 Lymph nodes metastasis (≤ 2 regions vs. > 2 regions) 0.432 (0.296, 0.629)  < 0.001 0.422 (0.289, 0.616)  < 0.001
 Distant metastasis (yes vs. no) 2.183 (0.912, 5.227) 0.080 2.514 (1.050, 6.018) 0.039
 Position (antrum vs. others) 0.965 (0.707, 1.318) 0.824 0.945 (0.693, 1.290) 0.723
 TNM stage (I, II vs III, IV) 3.775 (1.735, 8.210) 0.001 3.947 (1.810, 8.607) 0.001
 Size (< 4 cm vs. ≥ 4 cm) 2.571 (1.256, 5.264) 0.010 2.505 (1.223, 5.131) 0.012
 IRF-2 (positive vs. negative) 2.913 (1.538, 5.518) 0.001 2.517 (1.337, 4.738) 0.004
Multivariate analyses
 IRF-2 (positive vs. negative) 3.335 (1.736, 6.404)  < 0.001 2.756 (1.451, 5.234) 0.002
 Size (< 4 cm vs. ≥ 4 cm) 1.628 (0.760, 3.485) 0.209 1.544 (0.713, 3.347) 0.271
 TNM stage (I, II vs. III, IV) 3.495 (1.516, 8.058) 0.003 3.522 (1.509, 8.220) 0.004
  1. The Cox proportional hazards regression model was used in the univariate analysis. Multivariate analysis and Cox proportional hazards regression models were used in the multivariate analysis. Variables were adopted for their prognostic significance by univariate analysis with forward stepwise selection (forward, likelihood ratio). Variables were adopted for prognostic significance using univariate analysis (P < 0.05). 95% CI, 95% confidence interval